Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BRR6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Burkitt lymphoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + D-glucose | - |
Homo sapiens | AMP + D-glucose 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADP-dependent glucokinase | - |
Homo sapiens |
ADPGK | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | ADPGK knock-out Ramos BL cells display abated in vitro and in vivo tumour aggressiveness, via tumour-macrophage co-culture, migration and Zebrafish xenograft studies. Perturbed glycolysis and visibly reduced markers of Warburg effect in ADPGK knock-out cells, finally leading to apoptosis. Knock-out cells show repression of MYC proto-oncogene, and up to four-fold reduction in accumulated mutations in translocated MYC | Homo sapiens |
physiological function | the enzyme plays a major role in T-cell activation and induction of Warburg effect | Homo sapiens |