Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one | - |
Homo sapiens | |
R59022 | i.e. 6-[2-[4-[(4-Fluorophenyl)phenylmethylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one | Homo sapiens | |
R59949 | i.e. 3-[2-(4-[bis-(4-fluorophenyl)methylene]-1-piperidinyl)ethyl]-2, 3-dihydro-2-thioxo-4(1H)quinazolinone | Homo sapiens | |
ritanserin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endosome | - |
Homo sapiens | 5768 | - |
Golgi apparatus | - |
Homo sapiens | 5794 | - |
nucleus | - |
Homo sapiens | 5634 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | Homo sapiens | - |
ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75912 | - |
- |
Homo sapiens | P23743 | - |
- |
Homo sapiens | P49619 | - |
- |
Homo sapiens | P52429 | - |
- |
Homo sapiens | P52824 | - |
- |
Homo sapiens | Q13574 | - |
- |
Homo sapiens | Q16760 | - |
- |
Homo sapiens | Q5KSL6 | - |
- |
Homo sapiens | Q86XP1 | - |
- |
Homo sapiens | Q9Y6T7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
acute myeloid leukemia cell | - |
Homo sapiens | - |
breast cancer cell | - |
Homo sapiens | - |
cervical carcinoma cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
colorectal cancer cell | - |
Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
hepatoma cell | - |
Homo sapiens | - |
lung adenocarcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | - |
Homo sapiens | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKalpha | isoform | Homo sapiens |
DGKbeta | isoform | Homo sapiens |
DGKdelta | isoform | Homo sapiens |
DGKepsilon | isoform | Homo sapiens |
DGKeta | isoform | Homo sapiens |
DGKgamma | isoform | Homo sapiens |
DGKiota | isoform | Homo sapiens |
DGKkappa | isoform | Homo sapiens |
DGKtheta | isoform | Homo sapiens |
DGKzeta | isoform | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme isoforms control cancer cell survival, proliferation, and angiogenesis by regulating Akt/mTOR and MAPK/ERK pathways. In addition, some enzyme isoforms control cancer cell migration by regulating the activities of the Rho GTPases Rac1 and RhoA | Homo sapiens |