Cloned (Comment) | Organism |
---|---|
cloning from strain JM101, overexpression in strain BL21(DE3) | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amiclenomycin | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic analysis | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | Escherichia coli | enzyme is obligate catalyzing the second step in the biosynthesis of vitamin H, i.e. biotin | S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme from strain BL21(DE3) | Escherichia coli |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate | ping pong kinetics, reaction mechanism, via a enzyme-pyridoxamine phosphate, a quinonoid intermediate | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | enzyme is obligate catalyzing the second step in the biosynthesis of vitamin H, i.e. biotin | Escherichia coli | S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate | - |
r | |
S-adenosyl-L-methionine + 8-amino-7-oxononanoate | stereospecific amination | Escherichia coli | S-adenosyl-4-methylthio-2-oxobutanoate + (7S,8R)-diaminononanoate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
7,8-diaminopelargonate synthase | - |
Escherichia coli |
DAPA synthase | - |
Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Escherichia coli |