General Stability | Organism |
---|---|
2-oxoglutarate and pyridoxal 5'-phosphate protects against thermal denaturation | Meyerozyma guilliermondii |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-Diaminopropionate | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
2,4-diaminobutyrate | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
alanine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
beta-Alanine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
glycine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
L-lysine | noncompetitive inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
L-ornithine | mixed inhibition with respect to delta-aminovalerate, competitive inhibition to 2-oxoglutarate | Meyerozyma guilliermondii | |
additional information | alpha-aminobutyrate, 4-aminobutyrate, alpha-aminovalerate and epsilon-aminocaproate does not cause any inhibition | Meyerozyma guilliermondii |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
3.6 | - |
2-oxoglutarate | pH 7.8, 35°C | Meyerozyma guilliermondii | |
4.9 | - |
delta-aminovaleric acid | pH 7.8, 35°C | Meyerozyma guilliermondii |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
2 * 60000, SDS-PAGE | Meyerozyma guilliermondii |
118000 | - |
gel filtration | Meyerozyma guilliermondii |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-aminopentanoate + 2-oxoglutarate | Meyerozyma guilliermondii | enzyme is strongly induced in cells grown on delta-aminovalerate or on lysine as only nitrogen source | 5-oxovalerate + L-glutamate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Meyerozyma guilliermondii | - |
var.membranaefaciens | - |
Purification (Comment) | Organism |
---|---|
- |
Meyerozyma guilliermondii |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
20.8 | - |
- |
Meyerozyma guilliermondii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutyrate + 2-oxoglutarate | relative activity 40% | Meyerozyma guilliermondii | succinic semialdehyde + L-glutamate | - |
r | |
5-aminopentanoate + 2-oxoglutarate | - |
Meyerozyma guilliermondii | 5-oxovalerate + L-glutamate | - |
r | |
5-aminopentanoate + 2-oxoglutarate | enzyme is strongly induced in cells grown on delta-aminovalerate or on lysine as only nitrogen source | Meyerozyma guilliermondii | 5-oxovalerate + L-glutamate | - |
r | |
glycine + 2-oxoglutarate | relative activity 1% | Meyerozyma guilliermondii | glyoxalate + L-glutamate | - |
r | |
L-leucine + 2-oxoglutarate | relative activity 10% | Meyerozyma guilliermondii | 4-methyl-2-oxopentanoate + L-glutamate | - |
r | |
L-norleucine + 2-oxoglutarate | relative activity 4.8% | Meyerozyma guilliermondii | 2-oxohexanoate + L-glutamate | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 60000, SDS-PAGE | Meyerozyma guilliermondii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Meyerozyma guilliermondii |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
preserves 50% of its activity after being heated for 7 min, in presence of 2-oxoglutarate | Meyerozyma guilliermondii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | 8.5 | - |
Meyerozyma guilliermondii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | Km 0.0227 mM | Meyerozyma guilliermondii |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
5 | - |
beta-Alanine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
5.6 | - |
L-ornithine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
7 | - |
2,3-Diaminopropionate | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
9.5 | - |
ornithine | pH 7.8, 35°C, mixed inhibition | Meyerozyma guilliermondii | |
10 | - |
glycine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
11.5 | - |
2,4-diaminobutyrate | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
12.5 | - |
L-lysine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
15 | - |
alanine | pH 7.8, 35°C, competitive inhibition with respect to 2-oxoglutarate | Meyerozyma guilliermondii | |
16 | - |
beta-Alanine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
50 | - |
2,3-Diaminopropionate | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
90 | - |
glycine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
120 | - |
alanine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
120 | - |
lysine | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii | |
190 | - |
2,4-diaminobutyrate | pH 7.8, 35°C, noncompetitive inhibition with respect to delta-aminovalerate | Meyerozyma guilliermondii |