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Literature summary for 2.6.1.11 extracted from

  • Joshi, V.; Joshi, M.; Silwal, D.; Noonan, K.; Rodriguez, S.; Penalosa, A.
    Systematized biosynthesis and catabolism regulate citrulline accumulation in watermelon (2019), Phytochemistry, 162, 129-140 .
    View publication on PubMed
Search for more literature for 2.6.1.11

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N2-acetyl-L-ornithine + 2-oxoglutarate Citrullus lanatus
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 N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
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 ?

Organism

Organism UniProt Comment Textmining
Citrullus lanatus
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 cv. Charleston Gray
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Source Tissue

Source Tissue Comment Organism Textmining
fruit amino acid profiling of various tissues of Citrullus lanatus cv. Charleston Gray during plant development confirms progressive accumulation of citrulline only in the fruit flesh and rind tissues. Citrulline content is positively correlated with precursor (ornithine) and by-product (arginine) amino acids during fruit ripening Citrullus lanatus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N2-acetyl-L-ornithine + 2-oxoglutarate
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 Citrullus lanatus N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
N-acetylornithine aminotransferase
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 Citrullus lanatus
N-AOA
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 Citrullus lanatus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
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 Citrullus lanatus

General Information

General Information Comment Organism
metabolism N-acetylornithine aminotransferase (N-AOA) catalyzes a step in ornithine and citrulline biosynthesis. Genetic variation in the partitioning of citrulline and related amino acids in the flesh and rind tissues is confirmed in a sub-set of watermelon cultivars. No correlation is established between morphological fruit traits (size and rind properties) and citrulline content. Expression of N-AOA involved in the production of N-acetylornithine and N-acetylornithine deacetylase (AOD-3) involved in ornithine synthesis coincide with increasing accumulation of citrulline in flesh and rind tissues during fruit development. Downregulation N-acetylornithine-glutamate acetyltransferase (N-AOGA) suggests the subordinate role of the non-cyclic pathway in citrulline synthesis. Eccentricity between citrulline accumulation and expression of carbamoyl phosphate synthases (CPS-1, CPS-2) during fruit development suggests that the localized synthesis of carbamoyl phosphates may not be required for citrulline synthesis. Regulation of the citrulline metabolism, overview Citrullus lanatus