Cloned (Comment) | Organism |
---|---|
semiquantitative real-time PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | lentivirus-shRNA mediated AGPS silencing in Hep-G2/ADM and U-87MG/DDP cancer cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | Uniprot | Homo sapiens | 5777 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00116 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Homo sapiens | - |
glioma cell line | the enzyme is upregulated in multiple types of cancer cells and primary tumors | Homo sapiens | - |
Hep-G2/ADM cell | a doxorubicin-resistant cell line | Homo sapiens | - |
hepatic carcinoma cell | - |
Homo sapiens | - |
hepatoma cell line | the enzyme is upregulated in multiple types of cancer cells and primary tumors | Homo sapiens | - |
U-87MG/DDP cell | a cisplatin-resistant cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
AGPS | - |
Homo sapiens |
alkylglyceronephosphate synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the enzyme is upregulated in multiple types of cancer cells and primary tumors | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of enzyme AGPS restores the drug sensitivity in glioma U-87MG/DDP and hepatic carcinoma Hep-G2/ADM cell lines. Silencing of AGPS leads to reduced cellular level of lysophosphatidic acid, lysophosphatidic acid-ether and prostaglandin E2, which can fuel aggressive and progress of cancer. Knockdown of AGPS also results in downregulation of multi-drug resistance proteins and anti-apoptosis proteins | Homo sapiens |
physiological function | the enzyme catalyzes the critical step in ether lipid synthesis | Homo sapiens |