Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28907 | bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | - |
Mus musculus | P56528 | bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | - |
Synonyms | Comment | Organism |
---|---|---|
CD38 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | gene silencing of CD38 does not inhibit NAADP synthesis in intact Jurkat T cells. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose are efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme | Homo sapiens |
physiological function | gene silencing of CD38 does not inhibit NAADP synthesis in thymus or spleen obtained from CD38 knock out mice | Mus musculus |