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Literature summary for 2.4.3.1 extracted from
- The inhibitory Role of alpha2,6-sialylation in adipogenesis (2017), J. Biol. Chem., 292, 2278-2286 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q64685 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | - |
Mus musculus | - |
| abdominal adipose tissue | - |
Mus musculus | - |
| adipocyte | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CMP-N-acetyl-beta-neuraminate + integrin-beta1 | - |
Mus musculus | CMP + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta-galactoside alpha2,6-sialyltransferase-1 | - |
Mus musculus |
| ST6Gal1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is responsible for the biosynthesis of alpha2,6-linked sialic acid in N-linked glycans | Mus musculus |
| physiological function | enzyme overexpression in differentiating 3T3-L1 cells inhibits adipogenesis with increased phosphorylation of focal adhesion kinase. The enzyme has an inhibitory role in adipogenesis through integrin-beta1 activation | Mus musculus |
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