Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-3-phenylprop-2-enoic acid | - |
Escherichia coli | |
(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | uncompetitive inhibition | Escherichia coli | |
2,3,5-trihydroxy-6',7-dimethoxyflavone | - |
Escherichia coli | |
2H-1-benzopyran-2-one | uncompetitive inhibition | Escherichia coli | |
3,3',4',5-tetrahydroxy-6-methoxyflavone | mixed-type inhibition | Escherichia coli | |
4,4'-[(2R,3S)-2,3-dimethylbutane-1,4-diyl]di(benzene-1,2-diol) | competitive inhibition | Escherichia coli | |
4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one | - |
Escherichia coli | |
6-methoxy-2-oxo-2H-1-benzopyran-7-yl 6-O-[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]-beta-D-glucopyranoside | uncompetitive inhibition | Escherichia coli | |
7-deazaxanthine | non-competitive inhibition | Escherichia coli | |
7-hydroxy-6-methoxy-2H-1-benzopyran-2-one | non-competitive inhibition | Escherichia coli | |
8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one | uncompetitive inhibition | Escherichia coli | |
flavone | uncompetitive inhibition | Escherichia coli | |
additional information | natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors, in vitro biochemical inhibition, mechanistic, and in silico modeling and molecular docking studies, enzyme-bound structure modelling, overview. No inhibition by 4',5,7-trihydroxyflavone, 5,7-dihydroxyflavone, 9,10-dimethoxy-5,6,9,12-tetrahydro-2H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium, [(1R,9aR)-octahydro-2H-quinolizin-1-yl]methanol, 3,4,5-trihydroxybenzoic acid, and 4-hydroxy-3-methoxybenzoic acid. Cytotoxicity MTT assay on 3T3 cell line | Escherichia coli | |
tipiracil | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | Escherichia coli | - |
thymidine + phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0C037 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
thymine + 2-deoxy-alpha-D-ribose 1-phosphate | - |
Escherichia coli | thymidine + phosphate | - |
r |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics, Lineweaver-Burk plots | Escherichia coli | |
0.044 | - |
4,4'-[(2R,3S)-2,3-dimethylbutane-1,4-diyl]di(benzene-1,2-diol) | pH 7.0, 30°C | Escherichia coli | |
0.0768 | - |
3,3',4',5-tetrahydroxy-6-methoxyflavone | pH 7.0, 30°C | Escherichia coli | |
0.1131 | - |
2,3,5-trihydroxy-6',7-dimethoxyflavone | pH 7.0, 30°C | Escherichia coli | |
0.1811 | - |
8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one | pH 7.0, 30°C | Escherichia coli | |
0.1934 | - |
7-hydroxy-6-methoxy-2H-1-benzopyran-2-one | pH 7.0, 30°C | Escherichia coli | |
0.1951 | - |
flavone | pH 7.0, 30°C | Escherichia coli | |
0.2385 | - |
(6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline | pH 7.0, 30°C | Escherichia coli | |
0.2952 | - |
6-methoxy-2-oxo-2H-1-benzopyran-7-yl 6-O-[(2R,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]-beta-D-glucopyranoside | pH 7.0, 30°C | Escherichia coli | |
0.3442 | - |
4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one | pH 7.0, 30°C | Escherichia coli | |
0.3497 | - |
(2E)-3-phenylprop-2-enoic acid | pH 7.0, 30°C | Escherichia coli | |
0.4203 | - |
2H-1-benzopyran-2-one | pH 7.0, 30°C | Escherichia coli |