Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2''-deoxy-beta-D-threo-pentafuranosyl)thymine | - |
Escherichia coli | |
1-(2'-deoxy-beta-D-threo-pentafuranosyl)thymine | - |
Escherichia coli | |
3'-amino-3'-deoxythymidine | - |
Escherichia coli | |
3'-Deoxythymidine | - |
Escherichia coli | |
5'-azido-5'-deoxythymidine | - |
Escherichia coli | |
5'-bromo-5'-deoxythymidine | - |
Escherichia coli | |
5'-chloro-5'-deoxythymidine | - |
Escherichia coli | |
5'-iodo-5'-deoxythymidine | - |
Escherichia coli | |
ftorafur | ftorafur is also called tegafur | Escherichia coli | |
methyluridine | - |
Escherichia coli | |
uridine | - |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.28 | - |
4-thiothymidine | 25°C, pH 6.5 | Escherichia coli | |
0.28 | - |
4-thiothymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.3 | - |
thymidine | 25°C, pH 6.5 | Escherichia coli | |
0.3 | - |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine | 25°C, pH 6.5 | Escherichia coli | |
0.3 | - |
5'-chloro-5'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.3 | - |
thymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.3 | - |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.32 | - |
2'-deoxyuridine | - |
Escherichia coli | |
0.33 | - |
1-(2',6'-dideoxy-beta-D-ribo-hexafuranosyl)thymine | 25°C, pH 6.5 | Escherichia coli | |
0.33 | - |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.35 | - |
3'-deoxy-2',3'-didehydrothymidine | 25°C, pH 6.5 | Escherichia coli | |
0.35 | - |
1-(2',6'-dideoxy-alpha-L-lyxo-hexafuranosyl)thymine | 25°C, pH 6.5 | Escherichia coli | |
0.35 | - |
3'-deoxy-2',3'-didehydrothymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.35 | - |
1-(2',6'-dideoxy-alpha-L-lyxohexafuranosyl)thymine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.4 | - |
5'-Deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.4 | - |
3'-amino-3'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.4 | - |
5'-amino-5'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.4 | - |
5'-Deoxythymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.4 | - |
3'-amino-3'-deoxythymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.4 | - |
5'-amino-5'-deoxythymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli | P07650 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-(2',6'-dideoxy-alpha-L-lyxo-hexafuranosyl)thymine + phosphate | - |
Escherichia coli | ? | - |
? | |
1-(2',6'-dideoxy-alpha-L-lyxohexafuranosyl)thymine + phosphate | - |
Escherichia coli | thymine + 2,6-dideoxy-L-lyxohexafuranose 1-phosphate | - |
? | |
1-(2',6'-dideoxy-beta-D-ribo-hexafuranosyl)thymine + phosphate | - |
Escherichia coli | ? | - |
? | |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine + phosphate | - |
Escherichia coli | ? | - |
? | |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine + phosphate | - |
Escherichia coli | thymine + 2,6-dideoxy-D-ribohexafuranose 1-phosphate | - |
? | |
2'-deoxyuridine + phosphate | - |
Escherichia coli | ? | - |
? | |
3'-amino-3'-deoxythymidine + phosphate | - |
Escherichia coli | ? | - |
? | |
3'-amino-3'-deoxythymidine + phosphate | at pH 8.0 | Escherichia coli | ? | - |
? | |
3'-deoxy-2',3'-didehydrothymidine + phosphate | - |
Escherichia coli | ? | - |
? | |
3'-deoxy-2',3'-didehydrothymidine + phosphate | - |
Escherichia coli | thymine + 2,3-dideoxy-2,3-didehydro-D-ribose 1-phosphate | - |
? | |
4-thiothymidine + phosphate | - |
Escherichia coli | 4-thiothymine + 2-deoxy-D-ribose 1-phosphate | - |
? | |
4-thiothymidine + phosphate | - |
Escherichia coli | ? | - |
? | |
5'-amino-5'-deoxythymidine + phosphate | - |
Escherichia coli | ? | - |
? | |
5'-amino-5'-deoxythymidine + phosphate | - |
Escherichia coli | thymine + 2,5-dideoxy-5-amino-D-ribose 1-phosphate | - |
? | |
5'-chloro-5'-deoxythymidine + phosphate | - |
Escherichia coli | ? | - |
? | |
5'-deoxythymidine + phosphate | - |
Escherichia coli | ? | - |
? | |
5'-deoxythymidine + phosphate | - |
Escherichia coli | thymine + 2,5-dideoxy-D-ribose 1-phosphate | - |
? | |
additional information | 3'-amino-3'-deoxythymidine is not a thymidine phosphorylase substrate at pH 6.5, no activity with uridine and methyluridine | Escherichia coli | ? | - |
? | |
thymidine + phosphate | - |
Escherichia coli | thymine + 2-deoxy-D-ribose 1-phosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
1-(2',6'-dideoxy-beta-D-ribo-hexafuranosyl)thymine | 25°C, pH 6.5 | Escherichia coli | |
0.1 | - |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.4 | - |
3'-deoxy-2',3'-didehydrothymidine | 25°C, pH 6.5 | Escherichia coli | |
0.4 | - |
3'-deoxy-2',3'-didehydrothymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.45 | - |
1-(2',6'-dideoxy-alpha-L-lyxo-hexafuranosyl)thymine | 25°C, pH 6.5 | Escherichia coli | |
0.45 | - |
1-(2',6'-dideoxy-alpha-L-lyxohexafuranosyl)thymine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.58 | - |
5'-amino-5'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.58 | - |
5'-amino-5'-deoxythymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
0.6 | - |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine | 25°C, pH 6.5 | Escherichia coli | |
0.6 | - |
1-(2',6'-dideoxy-beta-D-ribohexafuranosyl)thymine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
1.1 | - |
3'-amino-3'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
1.1 | - |
3'-amino-3'-deoxythymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
1.7 | - |
5'-chloro-5'-deoxythymidine | - |
Escherichia coli | |
35 | - |
2'-deoxyuridine | - |
Escherichia coli | |
63 | - |
4-thiothymidine | 25°C, pH 6.5 | Escherichia coli | |
63 | - |
4-thiothymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
198 | - |
thymidine | 25°C, pH 6.5 | Escherichia coli | |
198 | - |
thymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli | |
260 | - |
5'-Deoxythymidine | - |
Escherichia coli | |
260 | - |
5'-Deoxythymidine | in 50 mM potassium phosphate buffer (pH 6.5), at 25°C | Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Escherichia coli |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.1 | 6.8 | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
uridine | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli | |
0.12 | - |
methyluridine | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli | |
0.4 | - |
5'-bromo-5'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.4 | - |
5'-iodo-5'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.4 | - |
5'-bromo-5'-deoxythymidine | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli | |
0.4 | - |
5'-iodo-5'-deoxythymidine | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli | |
0.45 | - |
ftorafur | 25°C, pH 6.5 | Escherichia coli | |
0.45 | - |
1-(2''-deoxy-beta-D-threo-pentafuranosyl)thymine | 25°C, pH 6.5 | Escherichia coli | |
0.45 | - |
ftorafur | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli | |
0.45 | - |
1-(2'-deoxy-beta-D-threo-pentafuranosyl)thymine | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli | |
0.6 | - |
3'-amino-3'-deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.6 | - |
3'-amino-3'-deoxythymidine | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli | |
0.85 | - |
3'-Deoxythymidine | 25°C, pH 6.5 | Escherichia coli | |
0.85 | - |
3'-Deoxythymidine | in 50 mM potassium phosphate buffer, pH 6.5, 25°C | Escherichia coli |