Literature summary for 2.4.1.B62 extracted from

Vesenka, G.D.; Majumdar, A.P.; Dubick, M.A.; Lyerly, D.M.; Wilkins, T.D.; Silva, J.; Geokas, M.C.
Stimulation of enzyme secretion from isolated pancreatic acini by Clostridium difficile toxin B (1986), Toxicol. Lett., 34, 261-269.

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Organism

Organism	UniProt	Comment	Textmining
Clostridioides difficile	-	-	-

General Information

General Information	Comment	Organism
physiological function	toxin B stimulates secretion from isolated pancreatic acini. Doses of toxin B from 10-30 ng/ml increases enzyme secretion by 15-20%, doses between 30 ng and 60 ng/ml show a regression of this effect, whereafter the rate of secretion of amylase, trypsinogen, and chymotrypsinogen increases with increasing concentrations of the toxin. Toxin B concentration of 800 ng/ml enhances amylase, trypsinogen and chymotrypsinogen secretion by 119%, 185% and 195%, respectively, when compared with the basal level	Clostridioides difficile

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Release 2023.1 (January 2023)