Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
AGS cell | - |
Homo sapiens | - |
AGS cell | low expression of FUT1-6 and FUT9, highest expression of FUT10, FUT11 is absent | Homo sapiens | - |
gastrointestinal cancer cell | - |
Homo sapiens | - |
GP-202 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
HT-29 cell | very low expression of FUT1, FUT3, FUT6 and FUT9, low expression of FUT2, FUT5 and FUT10, higher expression of FUT4, highest expression of FUT11 | Homo sapiens | - |
IPA-220 cell | - |
Homo sapiens | - |
KATO-III cell | - |
Homo sapiens | - |
KATO-III cell | very low expression of FUT1, low expression of FUT2, higher expression of FUT4-6, highest expression of FUT3 and FUT10-11 | Homo sapiens | - |
MKN-45 cell | - |
Homo sapiens | - |
MKN-45 cell | very low expression of FUT1, FUT5 and FUT6, low expression of FUT2, higher expression of FUT9-11, FUT3 is absent, highest expression of FUT4 | Homo sapiens | - |
additional information | low expression of FUT1-6 and FUT9 in GP-202 cells, but highest expression of FUT10 and FUT11. Very low expression of FUT1 in IPA-220 cells, low expression of FUT2, higher expression of FUT3-4, FUT6 and FUT10-11, highest expression of FUT5 and FUT9 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Fucalpha(1-2)Galbeta(1-3)GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP-L-fucose | - |
Homo sapiens | Fucalpha(1-2)Galbeta(1-3)[Fucalpha(1-4)]GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP | - |
? | |
Fucalpha(1-2)Galbeta(1-4)GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP-L-fucose | - |
Homo sapiens | Fucalpha(1-2)Galbeta(1-4)[Fucalpha(1-3)]GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP | - |
? | |
Galbeta(1-3)GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP-L-fucose | - |
Homo sapiens | Galbeta(1-3)[Fucalpha(1-4)]GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP | - |
? | |
Galbeta(1-4)GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP-L-fucose | - |
Homo sapiens | Galbeta(1-4)[Fucalpha(1-3)]GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP | - |
? | |
GDP-beta-L-fucose + Fucalpha(1->2)Galbeta(1->3)GlcNAc-(CH2)3-NHCO-(CH2)5-NH-biotin | - |
Homo sapiens | ? | - |
? | |
GDP-beta-L-fucose + Fucalpha1,2Galbeta(1->4)GlcNAc-(CH2)3-NHCO-(CH2)5-NH-biotin | - |
Homo sapiens | ? | - |
? | |
GDP-beta-L-fucose + Galbeta(1->3)GlcNAc-(CH2)3-NHCO-(CH2)5-NH-biotin | - |
Homo sapiens | ? | - |
? | |
GDP-beta-L-fucose + Galbeta(1->4)GlcNAc-(CH2)3-NHCO-(CH2)5-NH-biotin | - |
Homo sapiens | ? | - |
? | |
GDP-beta-L-fucose + NeuAcalpha(2->3)Galbeta(1->3)GlcNAc-(CH2)3-NHCO-(CH2)5-NH-biotin | - |
Homo sapiens | ? | - |
? | |
GDP-beta-L-fucose + NeuAcalpha(2->3)Galbeta(1->4)GlcNAc-(CH2)3-NHCO-(CH2)5-NH-biotin | - |
Homo sapiens | ? | - |
? | |
additional information | FUT6 can synthesize sialyl Lewis x in KATO III cells whereas FUT5 is most likely responsible for the synthesis of this epitope in HT29 and MKN45 cells. FUT3 and to a lower extent FUT5 have the capability to synthesize sialyl Lewis a | Homo sapiens | ? | - |
? | |
additional information | the enzyme transfers fucose from the GDP-fucose donor onto different glycoconjugate acceptors, such as, glycoproteins, glycolipids and oligosaccharides. Isoforms FUT3 to FUT7 and FUT9 to FUT11 belong to the group of alpha1,3/4-fucosyltransferases. FUT3 predominantly exhibits alpha1,4-fucosyltransferase activity synthesizing Lewis a, NeuAcalpha2,3Galbeta(1->3)[Fucalpha(1->4)]GlcNAc-R and Lewis b, and a minor alpha1,3-FUT activity, synthesizing Lewis x, sialyl Lewis x and Lewis y. FUT5 and FUT6 synthesize Lewis x and NeuAcalpha2,3Galbeta(1->4)[Fucalpha(1->3)]GlcNAc-R. FUT7 is an alpha1,3-FUT that synthesizes only sialyl Lewis x. FUT4 and FUT9 produce Lewis x and Lewis y. FUT10 and FUt11 exhibit alpha1,3-fucosyltransferase activity | Homo sapiens | ? | - |
? | |
NeuAcalpha(2-3)Galbeta(1-3)GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP-L-fucose | - |
Homo sapiens | NeuAcalpha(2-3)Galbeta(1-3)[Fucalpha(1-4)]GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP | - |
? | |
NeuAcalpha(2-3)Galbeta(1-4)GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP-L-fucose | - |
Homo sapiens | NeuAcalpha(2-3)Galbeta(1-4)[Fucalpha(1-3)]GlcNAcbeta(1-)(CH2)3-NHCO-(CH2)5-NH-biotin + GDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha-1,3/4-fucosyltransferase | - |
Homo sapiens |
alpha1,3/4-fucosyltransferase | - |
Homo sapiens |
alpha1,3/4-FUT | - |
Homo sapiens |
FucT III | isoform | Homo sapiens |
FucT V | isoform | Homo sapiens |
FucT VI | isoform | Homo sapiens |
FUT10 | - |
Homo sapiens |
FUT11 | - |
Homo sapiens |
FUT3 | - |
Homo sapiens |
FUT3 | isoform | Homo sapiens |
FUT4 | - |
Homo sapiens |
FUT5 | - |
Homo sapiens |
FUT5 | isoform | Homo sapiens |
FUT6 | - |
Homo sapiens |
FUT6 | isoform | Homo sapiens |
FUT7 | - |
Homo sapiens |
Fut9 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | decrease in FUT4 transcript levels in MKN45 confluent cells | down |
Homo sapiens | increase in mRNA levels of FUT5 and FUT6 in MKN45 confluent cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | final glycosylation step in sialyl Lewis x and sialyl Lewis a biosynthesis in MKN45 cell line is associated to FUT5, which efficiently fucosylates sialyl Lewis precursors on glycoproteins | Homo sapiens |
physiological function | fucosyltransferases are responsible for the synthesis of sialyl Lewis a and sialyl Lewis x in gastrointestinal cell lines | Homo sapiens |