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Literature summary for 2.4.1.221 extracted from
- Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis (2017), PLoS ONE, 12, e0187248 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R245A | mutation disrupts O-fucosyltransferase activity destabilizes the protein and abolishes Notch1 signaling during mouse somitogenesis | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q91ZW2 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pofut1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme (Pofut1), which transfers O-fucose to the EGF domains of the Notch1 receptor, is indispensable for Notch signaling activation | Mus musculus |
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