Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus pneumoniae | Q9L447 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | a 30-amino acid long sequence within the MurM protein is the main determinant of the specificity of the reaction, the addition of alanine versus serine | Streptococcus pneumoniae | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | the muropeptide composition of the pneumococcal cell walls is determined by the particular murM allele carried by the cells. After cloning of different murM alleles from several penicillin-resistant Streptococcus pneumoniae strains, each with a characteristic branched peptide pattern, and transformation into the penicillin-susceptible laboratory strain R36A, all transformants remain penicillin-susceptible, their cell wall composition changing in directions corresponding to the muropeptide pattern of the strain from which the murM allele is derived | Streptococcus pneumoniae |