Literature summary for 2.3.2.B1 extracted from

Filipe, s.R.; Pinho, M.G.; Tomasz, A.
Characterization of the murMN operon involved in the synthesis of branched peptidoglycan peptides in Streptococcus pneumoniae (2000), J. Biol. Chem., 275, 27768-27774.

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Organism

Organism	UniProt	Comment	Textmining
Streptococcus pneumoniae	Q9K307	penicillin-resistant strain	-
Streptococcus pneumoniae	Q9L447	penicillin-susceptible strain	-
Streptococcus pneumoniae Pen6	Q9K307	penicillin-resistant strain	-
Streptococcus pneumoniae R36A	Q9L447	penicillin-susceptible strain	-

General Information

General Information	Comment	Organism
physiological function	allelic replacement of the mosaic murM gene of strain Pen6 with murM of the penicillin-susceptible laboratory strain R36A causes enrichment of the peptidoglycan in linear muropeptides	Streptococcus pneumoniae
physiological function	inactivation of the murMN operon by insertion duplication mutagenesis does not cause any significant change in growth rate of the cultures, but leads to the disappearance of all branched muropeptide monomers and dimers accompanied by a parallel increase in the percentage of linear structured stem peptides and in the appearance of novel peptide structures. Allelic replacement of the mosaic murM gene of strain Pen6 with murM of the penicillin-susceptible laboratory strain R36A causes enrichment of the peptidoglycan in linear muropeptides	Streptococcus pneumoniae

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Release 2023.1 (January 2023)