Cloned (Comment) | Organism |
---|---|
expression in HEK-293 cell | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mitophagy is regulated by a positive ubiquitylation feedback loop in which the PINK1 kinase phosphorylates both ubiquitin and the E3 ubiquitin ligase parkin. This event recruits parkin to the mitochondria | Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60260 | isoform parkin | - |
Synonyms | Comment | Organism |
---|---|---|
parkin RBR E3 ubiquitin ligase | - |
Homo sapiens |
PRKN | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | miR-218 targets parkin and negatively regulates PINK1/parkin-mediated mitophagy. Overexpression of microRNA miR-218 reduces parkin mRNA levels, reducing protein content and deregulating the E3 ubiquitin ligase action. Following miR-218 overexpression, mitochondria result less ubiquitylated and the autophagy machinery fails to proceed with correct mitochondrial clearance | Homo sapiens |