Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96B02 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [SUMO-2]-N-terminal-amino acid | - |
Homo sapiens | [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[SUMO-2] | N-terminal mono-ubiquitylation of SUMO-2 primes it for poly-ubiquitylation by the Ubc13-UEV1 (ubiquitin-conjugating enzyme E2 variant 1) heterodimer | ? | |
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [Ube2W]-N-terminal-amino acid | - |
Homo sapiens | [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[Ube2W] | isoform Ube2W ubiquitylates its own N-terminus | ? |
Synonyms | Comment | Organism |
---|---|---|
Ubc16 | - |
Homo sapiens |
UBE2W | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Ube2W is an E2 ubiquitin-conjugating enzyme with specific protein N-terminal monoubiquitylation activity. Ube2W conjugates ubiquitin to its own N-terminus, but also to that of the small ubiquitin-like modifier SUMO in a manner dependent on the SUMO-targeted ubiquitin ligase RNF4, i.e.RING finger protein 4 | Homo sapiens |