Cloned (Comment) | Organism |
---|---|
chromosomal location, expression of the FLAG-tagged enzyme in Spodoptera frugiperda Sf9 cells and in COS-7 cells | Homo sapiens |
MFAT, DNA and amino acid sequence determination and analysis, localized on the X chromosome, expression of the N-terminally FLAG-tagged enzyme in Spodoptera frugierda Sf9 cells using the baculovirus transfection system, or in COS-7 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme plays an important role in lipid metabolism in human skin, overview | ? | - |
? | |
additional information | Homo sapiens | the multifunctional enzyme plays an important role in lipid metabolism in human skin | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q6E213 | MFAT | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Homo sapiens | - |
liver | very low expression level | Homo sapiens | - |
lung | - |
Homo sapiens | - |
lung | very low expression level | Homo sapiens | - |
pancreas | very low expression level | Homo sapiens | - |
skin | predominantly | Homo sapiens | - |
skin | high expression level | Homo sapiens | - |
testis | - |
Homo sapiens | - |
testis | very low expression level | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-hexadecandiol + palmitoyl-CoA | - |
Homo sapiens | ? | - |
? | |
1-hexadecanol + palmitoyl-CoA | - |
Homo sapiens | CoA + hexadecylpalmitate | - |
? | |
additional information | the enzyme plays an important role in lipid metabolism in human skin, overview | Homo sapiens | ? | - |
? | |
additional information | the multifunctional enzyme plays an important role in lipid metabolism in human skin | Homo sapiens | ? | - |
? | |
additional information | substrate specificity, overview, a human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters, overview, the enzyme catalyzes also the reactions of EC 2.3.1.20 and EC 2.3.1.22 | Homo sapiens | ? | - |
? | |
additional information | the multifunctional O-acetyltransferase is catalyzing the reactions of the wax synthase, of the diacylglycerol transferase, EC 2.3.1.20, of the monoacylglycerol transferase, EC 2.3.1.22, and of the acyl-CoA:retinol acyltransferase, EC 2.3.1.76, overview | Homo sapiens | ? | - |
? | |
palmitoyl-CoA + 1,2-hexadecandiol | - |
Homo sapiens | ? | - |
? | |
palmitoyl-CoA + all-trans-retinol | - |
Homo sapiens | ? | - |
? | |
palmitoyl-CoA + dioleoylglycerol | - |
Homo sapiens | ? | - |
? | |
palmitoyl-CoA + hexadecanol | - |
Homo sapiens | CoA + hexadecyl palmitate | - |
? | |
palmitoyl-CoA + monooleoylglycerol | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acyl-CoA:fatty acyl alcohol acyltransferase | - |
Homo sapiens |
MFAT | - |
Homo sapiens |
More | cf. EC 2.3.1.20 and EC 2.3.1.22, the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family | Homo sapiens |
More | the enzyme belongs to the acyl-CoA:diacylglycerol acyltransferase 2/acyl-CoA:monoacylglycerol acyltransferase, MGAT, gene family | Homo sapiens |
multifunctional O-acyltransferase | - |
Homo sapiens |
wax synthase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |