Literature summary for 2.3.1.5 extracted from

Xu, X.; Mathieu, C.; Berthelet, J.; Duval, R.; Bui, L.C.; Busi, F.; Dupret, J.M.; Rodrigues-Lima, F.
Human arylamine N-acetyltransferase 1 is inhibited by the dithiocarbamate pesticide thiram (2017), Mol. Pharmacol., 92, 358-365 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
thiram	irreversible inhibitor, modification of NAT1 catalytic cysteine residue	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P18440	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HaCaT cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl acetate + 3,4-dichloroaniline	-	Homo sapiens	4-nitrophenol + N-acetyl-3,4-dichloroaniline	-	?
4-nitrophenyl acetate + 4-aminobenzoic acid	-	Homo sapiens	4-nitrophenol + N-acetyl-4-aminobenzoic acid	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.023	-	thiram	37°C, pH not specified in the publication	Homo sapiens

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Release 2023.1 (January 2023)