Application | Comment | Organism |
---|---|---|
medicine | results show that DNA hypomethylation in the NAT1 gene is present in cancerous breast tissues thus indicating that this type of methylation may significantly influence the transcriptional activation of the gene. Therefore, hypomethylation of the NAT1 gene plays a significant role in breast carcinogenesis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | methylation status and the transcriptional activity of NAT1 in breast cancer tissues: methylation of NAT1 gene is identified in 39 of the breast carcinomas (54.2%), 23 normal (76.7%) and 25 benign breast tissue samples (80.6%). Breast cancer tissues show significantly lower methylation rates of the NAT1 promoters than the normal and benign tissues. Cancer tissues show lower methylation density rates than normal and benign breast tissues. Tissues that show aberrant methylation of NAT1 show significantly less mRNA expression compared with the unmethylated cases. 20 cancers from the methylated group show positive staining for the estrogen receptor (ER) (51.3%), while 72.7% from the unmethylated group stain positive | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
arylamine N-acetyltransferase 1 | - |
Homo sapiens |
NAT1 | - |
Homo sapiens |