Protein Variants | Comment | Organism |
---|---|---|
R64Q | structural basis of the effects of the common genetic polymorphism on NAT2 activity, enzyme and active site structure analysis, phenotype, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | Homo sapiens | NAT2 is responsible for the biotransformation of numerous arylamine drugs and carcinogens | CoA + an N-acetylarylamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11245 | NAT2; isozyme NAT2 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine | a conserved active site loop is involved in substrate recognition, structure analysis, Ser125 in NAT2 is proximal to the catalytic triad and faces a passageway to the catalytic core | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an arylamine | - |
Homo sapiens | CoA + an N-acetylarylamine | - |
? | |
acetyl-CoA + an arylamine | NAT2 is responsible for the biotransformation of numerous arylamine drugs and carcinogens | Homo sapiens | CoA + an N-acetylarylamine | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | construction of a high-quality model of a catalytic N-terminal region of NAT2, comprising residues 34-131, using the crystal structure of the Salmonella typhimurium NAT, PDB entry 1e2t, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
NAT | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |