Application | Comment | Organism |
---|---|---|
medicine | the combined therapy of enzyme and teniposide VM-26 is a therapeutic strategy for the treatment of human glioma | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + a sphingoid base | Homo sapiens | - |
an N-(stearoyl)-sphingoid base + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-172 cell | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
central nervous system | - |
Homo sapiens | - |
glioma cell | - |
Homo sapiens | - |
U-251MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
stearoyl-CoA + a sphingoid base | - |
Homo sapiens | an N-(stearoyl)-sphingoid base + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide synthase 1 | - |
Homo sapiens |
CerS1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme overexpression inhibits cell viability and induces cell death by activating endoplasmic reticulum stress, which induces lethal autophagy and inhibits PI3K/AKT signal pathway in U-251 and A-172 glioma cells. Enzyme overexpression also increases the sensitivity of U-251 and A-172 glioma cells to teniposide (VM-26) | Homo sapiens |