Literature summary for 2.3.1.291 extracted from

Frangioudakis, G.; Diakanastasis, B.; Liao, B.Q.; Saville, J.T.; Hoffman, N.J.; Mitchell, T.W.; Schmitz-Peiffer, C.
Ceramide accumulation in L6 skeletal muscle cells due to increased activity of ceramide synthase isoforms has opposing effects on insulin action to those caused by palmitate treatment (2013), Diabetologia, 56, 2697-701 .

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in L6 myotubes	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8N5B7	-	-

General Information

General Information	Comment	Organism
physiological function	overexpression of isoform Cers5 leads to accumulation of C16:0 ceramides. Presence of insulin has no effect on sphingomyelins, while palmitate treatment causes a significant decrease in several species, including the predominant C16:0 species. CerS5 knockdown reduces glycogen synthesis in the absence or presence of palmitate. Isoform CerS1 overexpression results in minor upregulation of endogenous CerS5	Homo sapiens

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Release 2023.1 (January 2023)