Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.269 extracted from

  • Gwin, C.M.; Prakash, N.; Christian Belisario, J.; Haider, L.; Rosen, M.L.; Martinez, L.R.; Rigel, N.W.
    The apolipoprotein N-acyl transferase Lnt is dispensable for growth in Acinetobacter species (2018), Microbiology, 164, 1547-1556 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.269

Protein Variants

Protein Variants Comment Organism
additional information generation of loss-of-function mutants of Lnt, i.e. lnt153::T26, phenotypes, overview Acinetobacter baumannii
additional information generation of loss-of-function mutants of Lnt, phenotypes, overview Acinetobacter baylyi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baumannii
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baylyi
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baylyi BD413
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baylyi ATCC 33305
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine Acinetobacter baumannii AB5075-UW
-
 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii A0A090B6R9
-
-
Acinetobacter baumannii AB5075-UW A0A090B6R9
-
-
Acinetobacter baylyi Q6FF00
-
-
Acinetobacter baylyi ATCC 33305 Q6FF00
-
-
Acinetobacter baylyi BD413 Q6FF00
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baumannii a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baylyi a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baylyi BD413 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baylyi ATCC 33305 a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?
a phosphoglycerolipid + an [apolipoprotein]-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 Acinetobacter baumannii AB5075-UW a 1-lyso-phosphoglycerolipid + a [lipoprotein]-N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
ALP N-acyltransferase UniProt Acinetobacter baumannii
lnt
-
 Acinetobacter baumannii
lnt
-
 Acinetobacter baylyi

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Acinetobacter baumannii
37
-
 assay at Acinetobacter baylyi

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Acinetobacter baumannii
7.2
-
 assay at Acinetobacter baylyi

General Information

General Information Comment Organism
malfunction Acinetobacter species can tolerate a complete loss-of-function mutation in gene lnt. Absence of a fully functional Lnt impairs modification of lipoproteins, increases outer membrane permeability and susceptibility to antibiotics, and alters normal cellular morphology. In addition, loss of lnt triggers a global transcriptional response to this added cellular stress. Without Lnt, the bacterial cell envelope becomes more permeable and modification of outer membrane lipoproteins is impaired. Cells of the lnt mutant have structural defects. The genome expression profile of Acinetobacter baylyi changes in response to lnt mutation. Phenotypes, overview Acinetobacter baylyi
malfunction Acinetobacter species can tolerate a complete loss-of-function mutation in gene lnt. Absence of a fully functional Lnt impairs modification of lipoproteins, increases outer membrane permeability and susceptibility to antibiotics, and alters normal cellular morphology. In addition, loss of lnt triggers a global transcriptional response to this added cellular stress. Without Lnt, the bacterial cell envelope becomes more permeable and modification of outer membrane lipoproteins is impaired. Phenotypes, overview Acinetobacter baumannii
metabolism genome expression profile of Acinetobacter baylyi changes in response to gene lnt mutation, overview Acinetobacter baylyi
physiological function proper acylation of outer membrane lipoprotein BamD requires enzyme Lnt in Acinetobacter baylyi. Lnt is required for full maturation of outer membrane lipoprotein BamD Acinetobacter baylyi