Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a therapeutic target in colorectal cancers | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an N-terminal-L-seryl-[histone H2A] | Homo sapiens | - |
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA | - |
? | |
acetyl-CoA + an N-terminal-L-seryl-[histone H4] | Homo sapiens | - |
an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q86UY6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + an N-terminal-L-seryl-[histone H2A] | - |
Homo sapiens | an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA | - |
? | |
acetyl-CoA + an N-terminal-L-seryl-[histone H4] | - |
Homo sapiens | an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N(alpha)-acetyltransferase 40 | - |
Homo sapiens |
Naa40 | - |
Homo sapiens |
NAT4 | - |
Homo sapiens |
NatD | - |
Homo sapiens |
Patt1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | depletion of Naa40 in HCT-116 and HT-29 colorectal cancer cells decreases cell survival by enhancing apoptosis. Naa40 knockdown in colon cancer cells activates the mitochondrial caspase-9-mediated apoptotic cascade | Homo sapiens |