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Literature summary for 2.3.1.250 extracted from

  • Galli, L.; Barnes, T.; Secrest, S.; Kadowaki, T.; Burrus, L.
    Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube (2007), Development, 134, 3339-3348.
    View publication on PubMed
Search for more literature for 2.3.1.250

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of HA-tagged human PORC to confirm the ability of hPORC RNAi constructs to knockdown hPORC expression Homo sapiens

Protein Variants

Protein Variants Comment Organism
H341D site-directed mutagenesis, catalytically inactive mutant Mus musculus
H341Q site-directed mutagenesis, catalytically inactive mutant Mus musculus
additional information overexpression of HA-tagged human PORC to confirm the ability of hPORC RNAi constructs to knockdown hPORC expression Homo sapiens
additional information the catalytically inactive porcupine is able to act as an inhibitor of endogenous porcupine, possibly via direct competition for substrate Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine Gallus gallus
-
 CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine Homo sapiens
-
 CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine Mus musculus
-
 CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine Gallus gallus
-
 CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine Homo sapiens
-
 CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine Mus musculus
-
 CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens Q9H237
-
-
Mus musculus Q9JJJ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
neural tube
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine
-
 Gallus gallus CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine
-
 Homo sapiens CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine
-
 Mus musculus CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine chicken substrate, and chimeric recombinant substrate containing amino acids 1-63 from mouse Wnt1 (-EPSLQL) and amino acids 64-370 from chicken Wnt1 (LSRKQ-) Gallus gallus CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine chicken substrate, and chimeric recombinant substrate containing amino acids 1-63 from mouse Wnt1 (-EPSLQL) and amino acids 64-370 from chicken Wnt1 (LSRKQ-) Homo sapiens CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt1]-L-serine chicken substrate, and chimeric recombinant substrate containing amino acids 1-63 from mouse Wnt1 (-EPSLQL) and amino acids 64-370 from chicken Wnt1 (LSRKQ-) Mus musculus CoA + [Wnt1]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine
-
 Gallus gallus CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine
-
 Homo sapiens CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine
-
 Mus musculus CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine chicken substrate, and substrate from Mus musculus Gallus gallus CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine chicken substrate, and substrate from Mus musculus Homo sapiens CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
(9Z)-hexadec-9-enoyl-CoA + [Wnt3a]-L-serine chicken substrate, and substrate from Mus musculus Mus musculus CoA + [Wnt3a]-O-(9Z)-hexadec-9-enoyl-L-serine
-
 ?
additional information vertebrate Wnt1 and Wnt3a possess at least one additional site for porcupine-mediated lipid-modification Homo sapiens ?
-
 ?
additional information vertebrate Wnt1 and Wnt3a possess at least one additional site for porcupine-mediated lipid-modification, localization of Wnt proteins in the chick neural tube, overview Gallus gallus ?
-
 ?

Synonyms

Synonyms Comment Organism
mPorcD
-
 Mus musculus

General Information

General Information Comment Organism
malfunction the catalytically inactive porcupine is able to act as an inhibitor of endogenous porcupine, possibly via direct competition for substrate Mus musculus
physiological function porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins, and promotes their activity in 293T cells, porcupine is required for Wnt activity in 293T cells, and porcupine/palmitoylation regulates the activity of Wnt1 and Wnt3a in 293T cells Homo sapiens
physiological function porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins, and promotes their activity in the chick neural tube, while it reduces the range of activity of Wnt1 and Wnt3a in the chick neural tube Mus musculus
physiological function porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins, it promotes the activity of endogenous Wnt1 and Wnt3a in the chick neural tube, ectopic expression of mouse porcupine in the chick neural tube steepens the Wnt1/Wnt3a proliferation gradient, but porcupine expression restricts the Wnt activity range and distribution in the chicken neural tube, overview Gallus gallus