Organism | UniProt | Comment | Textmining |
---|---|---|---|
Xenopus laevis | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | mRNA is strongly expressed in differentiated epithelial structures of the pronephric kidney | Xenopus laevis | - |
General Information | Comment | Organism |
---|---|---|
physiological function | knockdown of scp2 does not interfere with the patterning of the kidney along its proximo-distal axis, but dramatically decreases the size of the kidney, in particular the proximal tubules. This phenotype is accompanied by a reduction of lipid rafts, but is independent of the peroxisomal or transcriptional activities of scp2. Disrupting lipid microdomains by inhibiting cholesterol synthesis phenocopies the defects seen in scp2 morphants | Xenopus laevis |