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Literature summary for 2.1.1.B124 extracted from

  • Rorbach, J.; Boesch, P.; Gammage, PÖ.A.; Nicholls, T.J.J.; Pearce, S.F.; Patel, D.; Hauser, A.; Perocchi, F.; Minczuk, M.
    MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome (2014), Mol. Biol. Cell, 25, 2542-55 /.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cell Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HC36
-
-

Synonyms

Synonyms Comment Organism
MRM3
-
 Homo sapiens
RMTL1
-
 Homo sapiens
RNMTL1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function MRM2 and MRM3 are responsible for modification of nucleotides of the 16S rRNA A-loop, an essential component of the peptidyl transxadferase center. Inactivation of MRM2 or MRM3 in human cells by RNA interference results in respiratory incompetence as a consequence of diminished mitochondrial translation. Ineffective translation in MRM2- and MRM3-depleted cells results from aberxadrant assembly of the large subunit of the mitochondrial ribosome Homo sapiens