Cloned (Comment) | Organism |
---|---|
expression in HeLa cell | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UI43 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
FtsJ2 | - |
Homo sapiens |
MRM2 | - |
Homo sapiens |
RRMJ2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | MRM2 and MRM3 are responsible for modification of nucleotides of the 16S rRNA A-loop, an essential component of the peptidyl transxadferase center. Inactivation of MRM2 or MRM3 in human cells by RNA interference results in respiratory incompetence as a consequence of diminished mitochondrial translation. Ineffective translation in MRM2- and MRM3-depleted cells results from aberxadrant assembly of the large subunit of the mitochondrial ribosome | Homo sapiens |