Inhibitors | Comment | Organism | Structure |
---|---|---|---|
desmethylxanthohumol | competitive with respect to xanthohumol | Humulus lupulus | |
S-adenosyl-L-homocysteine | - |
Humulus lupulus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.018 | - |
desmethylxanthohumol | pH 7.5, 30°C | Humulus lupulus | |
0.286 | - |
S-adenosyl-L-methionine | pH 7.5, 30°C | Humulus lupulus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | bivalent cations (Mg2+, Fe2+, Zn2+, Cu2+, Ca2+, and Co2+) are not required for activity | Humulus lupulus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39265 | - |
- |
Humulus lupulus |
76000 | - |
gel filtration | Humulus lupulus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Humulus lupulus | B0ZB55 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + caffeic acid | - |
Humulus lupulus | S-adenosyl-L-homocysteine + ? | 7% of the activity with desmethylxanthohumol | ? | |
S-adenosyl-L-methionine + desmethylxanthohumol | - |
Humulus lupulus | S-adenosyl-L-homocysteine + xanthohumol | - |
? | |
S-adenosyl-L-methionine + xanthogalenol | 445% of the activity with desmethylxanthohumol | Humulus lupulus | S-adenosyl-L-homocysteine + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 39265, calculated | Humulus lupulus |
Synonyms | Comment | Organism |
---|---|---|
OMT1 | - |
Humulus lupulus |
S-adenosyl-L-methionine-dependent O-methyltransferase | - |
Humulus lupulus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | 37 | - |
Humulus lupulus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
- |
Humulus lupulus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
desmethylxanthohumol | pH 7.5, 30°C | Humulus lupulus | |
0.098 | - |
S-adenosyl-L-homocysteine | pH 7.5, 30°C | Humulus lupulus |
General Information | Comment | Organism |
---|---|---|
physiological function | OMT1 performs the final reaction in xanthohumol biosynthesis by methylating desmethylxanthohumol to form xanthohumol | Humulus lupulus |