Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92979 | - |
- |
Methanocaldococcus jannaschii | Q57977 | - |
- |
Methanocaldococcus jannaschii DSM 2661 | Q57977 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate specificity analysis by NMR binding and affinity study for RNA, overview. The enzyme is highly specific for pseudouridine. Methanocaldococcus jannaschii Nep1 binds to the yeast Nep1 RNA consensus sequence | Methanocaldococcus jannaschii | ? | - |
? | |
additional information | substrate specificity analysis by NMR binding and affinity study for RNA, overview. The enzyme is highly specific for pseudouridine. Methanocaldococcus jannaschii Nep1 binds to the yeast Nep1 RNA consensus sequence | Methanocaldococcus jannaschii DSM 2661 | ? | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-GAUPsiCAACGCC-3' | - |
Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-GAUmethylPsiCAACGCC-3' | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-GAUPsiCAACGCC-3' | - |
Methanocaldococcus jannaschii DSM 2661 | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-GAUmethylPsiCAACGCC-3' | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-PsiCAACGCC-3' | - |
Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-methylPsiCAACGCC-3' | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-PsiCAACGCC-3' | - |
Methanocaldococcus jannaschii DSM 2661 | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-methylPsiCAACGCC-3' | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGC--3' | - |
Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGC--3' | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGC--3' | - |
Methanocaldococcus jannaschii DSM 2661 | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGC--3' | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGCC-3' | - |
Methanocaldococcus jannaschii | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGCC-3' | - |
? | |
S-adenosyl-L-methionine + pseudouridine in 5'-UPsiCAACGCC-3' | - |
Methanocaldococcus jannaschii DSM 2661 | S-adenosyl-L-homocysteine + N1-methylpseudouridine in 5'-UmethylPsiCAACGCC-3' | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases | Homo sapiens |
dimer | Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases | Methanocaldococcus jannaschii |
Synonyms | Comment | Organism |
---|---|---|
Emg1 | - |
Homo sapiens |
MjNep1 | - |
Methanocaldococcus jannaschii |
Nep1 | - |
Homo sapiens |
Nep1 | - |
Methanocaldococcus jannaschii |
pseudouridine-N1-specific methyltransferase | - |
Homo sapiens |
pseudouridine-N1-specific methyltransferase | - |
Methanocaldococcus jannaschii |
ribosome assembly factor Nep1 | - |
Homo sapiens |
ribosome assembly factor Nep1 | - |
Methanocaldococcus jannaschii |
General Information | Comment | Organism |
---|---|---|
evolution | Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases | Homo sapiens |
evolution | Nep1 structure reveals a dimer with a fold similar to the SPOUT-class of RNA-methyltransferases | Methanocaldococcus jannaschii |
malfunction | a mutation in the human Nep1 homolog causes Bowen-Conradi syndrome, a severe developmental disorder | Homo sapiens |
physiological function | Nep1 acts as a methyltransferase in ribosome biogenesis | Homo sapiens |
physiological function | Nep1 acts as a methyltransferase in ribosome biogenesis | Methanocaldococcus jannaschii |