Literature summary for 2.1.1.202 extracted from

Gkatza, N.A.; Castro, C.; Harvey, R.F.; Heiss, M.; Popis, M.C.; Blanco, S.; Borneloev, S.; Sajini, A.A.; Gleeson, J.G.; Griffin, J.L.; West, J.A.; Kellner, S.; Willis, A.E.; Dietmann, S.; Frye, M.
Cytosine-5 RNA methylation links protein synthesis to cell metabolism (2019), PLoS Biol., 17, e3000297 .

Search for more literature for 2.1.1.202

Application

Application	Comment	Organism
additional information	changes in tRNA methylation profiles are sufficient to specify cellular metabolic states and efficiently adapt protein synthesis rates to cell stress	Mus musculus
additional information	changes in tRNA methylation profiles are sufficient to specify cellular metabolic states and efficiently adapt protein synthesis rates to cell stress	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of NSUN2 knockout mice (homozygous Nsun2Gt[D014D11]Wrs)	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleolus	-	Mus musculus	5730	-
nucleolus	-	Homo sapiens	5730	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O14717	-	-
Mus musculus	O55055	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
brain	-	Homo sapiens	-
dermal fibroblast	-	Homo sapiens	-
fibroblast	-	Mus musculus	-
follicular stem cell	-	Mus musculus	-
hair follicle	-	Mus musculus	-
skin	-	Mus musculus	-
skin	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
cytosine-5 RNA methyltransferase	-	Mus musculus
cytosine-5 RNA methyltransferase	-	Homo sapiens
NSUN2	-	Mus musculus
NSUN2	-	Homo sapiens
TRDMT1	-	Mus musculus
TRDMT1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
S-adenosyl-L-methionine	-	Mus musculus
S-adenosyl-L-methionine	-	Homo sapiens

Expression

Organism	Comment	Expression
Mus musculus	exposure to oxidative stress efficiently repressed NSUN2, causing a reduction of methylation at specific tRNA sites. Nucleophosmin (NPMI) is a marker for nucleolar stress, and a rapid, strong down-regulation of both NPMI and NSUN2 is observed upon arsenite treatment. Additional NSUN family members residing in the mitochondria (NSUN3, NSUN4) and cytoplasm (NSUN6) are similarly repressed in response to arsenite stress	down
Homo sapiens	exposure to oxidative stress efficiently repressed NSUN2, causing a reduction of methylation at specific tRNA sites. Nucleophosmin (NPMI) is a marker for nucleolar stress, and a rapid, strong down-regulation of both NPMI and NSUN2 is observed upon arsenite treatment. Additional NSUN family members residing in the mitochondria (NSUN3, NSUN4) and cytoplasm (NSUN6) are similarly repressed in response to arsenite stress	down

General Information

General Information	Comment	Organism
malfunction	exposure to oxidative stress efficiently repressed NSUN2, causing a reduction of methylation at specific tRNA sites. Loss of NSUN2 alters the biogenesis of tRNA-derived noncoding fragments (tRFs) in response to stress, leading to impaired regulation of protein synthesis. The intracellular accumulation of a specific subset of tRFs correlates with the dynamic repression of global protein synthesis	Homo sapiens
malfunction	exposure to oxidative stress efficiently repressed NSUN2, causing a reduction of methylation at specific tRNA sites. Loss of NSUN2 alters the biogenesis of tRNA-derived noncoding fragments (tRFs) in response to stress, leading to impaired regulation of protein synthesis. The intracellular accumulation of a specific subset of tRFs correlates with the dynamic repression of global protein synthesis. Disruption of the Nsun2 gene in mice causes global hypomethylation of tRNAs and a developmental growth retardation. The abnormal development of tissues including brain and skin is the result of impaired stem cell differentiation. The expression of NSUN2 is highly dynamic within tissues. For instance, NSUN2 is absent in quiescent stem cells in hair follicle bulges (BGs), steadily increases in progenitor cells in the hair germ, and is highest in the growing (anagen) hair bulb	Mus musculus
metabolism	enzyme NSUN2 plays a central role in regulation of the stress respone pathway, detailed overview. tRNAs play multiple regulatory roles in the adaptation of protein synthesis to the cellular stress response	Homo sapiens
metabolism	enzyme NSUN2 plays a central role in regulation of the stress response pathway, detailed overview. tRNAs play multiple regulatory roles in the adaptation of protein synthesis to the cellular stress response	Mus musculus
physiological function	the cytosine-5 RNA methyltransferase NSUN2 is a sensor for external stress stimuli. NSUN2-driven RNA methylation is functionally required to adapt cell cycle progression to the early stress response. The nucleolus, where NSUN2 resides, can act as a stress sensor. Dynamic changes of site-specific Methylcytosine (m5C) levels require NSUN2. m5C is required to balance anabolic and catabolic pathways during the stress response	Mus musculus
physiological function	the cytosine-5 RNA methyltransferase NSUN2 is a sensor for external stress stimuli. NSUN2-driven RNA methylation is functionally required to adapt cell cycle progression to the early stress response. The nucleolus, where NSUN2 resides, can act as a stress sensor. Dynamic changes of site-specific Methylcytosine (m5C) levels require NSUN2. m5C is required to balance anabolic and catabolic pathways during the stress response	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)