Literature summary for 1.8.4.B3 extracted from

Sagher, D.; Brunell, D.; Hejtmancik, J.F.; Kantorow, M.; Brot, N.; Weissbach, H.
Thionein can serve as a reducing agent for the methionine sulfoxide reductases (2006), Proc. Natl. Acad. Sci. USA, 103, 8656-8661.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8IXL7	-	-
Homo sapiens	Q9Y3D2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-methionine (R)-S-sulfoxide + dithiothreitol	-	Homo sapiens	L-methionine + dithiothreitol disulfide + H2O	-	?
L-methionine (R)-S-sulfoxide + thionein	-	Homo sapiens	L-methionine + thionein disulfide + H2O	-	?
L-methionine (R)-S-sulfoxide + thioredoxin	reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol	Homo sapiens	L-methionine + thioredoxin disulfide	-	?
L-methionine (R)-S-sulfoxide + thioredoxin	reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol	Homo sapiens	L-methionine + thioredoxin disulfide + H2O	-	?
L-methionine (R)-sulfoxide + dithiothreitol	-	Homo sapiens	L-methionine + dithiothreitol disulfide	-	?
additional information	zinc-containing metallothionein in the presence of EDTA can serve as a reducing agent. Thioredoxin can reduce oxidized thionein	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
hMsrB2	-	Homo sapiens
hMsrB3	-	Homo sapiens

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Release 2023.1 (January 2023)