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Literature summary for 1.8.1.9 extracted from

  • Cao, X.; Lilla, S.; Cao, Z.; Pringle, M.A.; Oka, O.B.V.; Robinson, P.J.; Szmaja, T.; van Lith, M.; Zanivan, S.; Bulleid, N.J.
    The mammalian cytosolic thioredoxin reductase pathway acts via a membrane protein to reduce ER-localised proteins (2020), J. Cell Sci., 133, jcs241976 .
    View publication on PubMed
Search for more literature for 1.8.1.9

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thioredoxin disulfide + NADPH + H+ Homo sapiens
-
 thioredoxin + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16881
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thioredoxin disulfide + NADPH + H+
-
 Homo sapiens thioredoxin + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
 Homo sapiens
TrxR1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function thioredoxin reductase system provides the minimal cytosolic components required for reducing proteins within the ER lumen Homo sapiens