Literature summary for 1.7.2.1 extracted from

Qin, X.; Chen, X.
Remote water-mediated proton transfer triggers inter-Cu electron transfer nitrite reduction activation in copper-containing nitrite reductase (2021), ChemBioChem, 22, 1405-1414 .

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
copper	-	Alcaligenes faecalis

Organism

Organism	UniProt	Comment	Textmining
Alcaligenes faecalis	P38501	-	-

General Information

General Information	Comment	Organism
metabolism	the driving force for electron transfer from type 1 copper to type 2 copper comes from a remote water-mediated triple-proton-coupled electron-transfer mechanism. In the high-pH proton channel, the water-mediated triple-proton transfer occurs from Glu113 to an intermediate water molecule, whereas in the primary channel, the transfer is from Lys128 to His260. Subsequently, the two channels employ another two or three distinct proton-transfer steps to deliver the proton to the nitrite substrate at the type 2 copper site	Alcaligenes faecalis

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Release 2023.1 (January 2023)