Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q5VYX0 | - |
- |
Rattus norvegicus | Q5U2W9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HK-2 cell | proximal renal tubular epithelial cell | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
RnlS | - |
Homo sapiens |
RnlS | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | in HK-2 cells, renalase inhibits TGF-1-mediated upregulation of alpha-smooth muscle actin and downregulation of E-cadherin. Increased levels of phospho-extracellular regulated protein kinases (p-ERK1/2) in TGF-1-stimulated cells are reversed by renalase cotreatment. When ERK1 is overexpressed, the inhibition of TGF-1-induced EMT and fibrosis mediated by renalase is attenuated | Homo sapiens |
physiological function | in rats with complete unilateral ureteral obstruction, the expression of renalase is markedly downregulated and adenoviral-mediated expression of renalase significantly attenuates renal interstitial fibrosis | Rattus norvegicus |