Literature summary for 1.6.3.5 extracted from

Wu, Y.; Quan, C.; Yang, Y.; Liang, Z.; Jiang, W.; Li, X.
Renalase improves pressure overload-induced heart failure in rats by regulating extracellular signal-regulated protein kinase 1/2 signaling (2021), Hypertens. Res., 44, 481-488 .

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q5U2W9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

General Information

General Information	Comment	Organism
physiological function	during transverse aortic constriction-induced heart failure, renalase is directly associated with P38 and extracellular signal-regulated protein kinase 1/2 signaling. Renalase inhibition attenuates the noradrenaline-induced hypertrophic response in vitro or the pressure overload-induced hypertrophic response in vivo. Recombinant renalase protein significantly alleviates pressure overload-induced cardiac failure and is associated with P38 and ERK1/2 signaling	Rattus norvegicus

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Release 2023.1 (January 2023)