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Literature summary for 1.6.2.4 extracted from
- Kinetic analysis of electron flux in cytochrome P450 reductases reveals differences in rate-determining steps in plant and mammalian enzymes (2015), Arch. Biochem. Biophys., 584, 107-115 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2',5'-ADP | - |
Arabidopsis thaliana |  |
| 2',5'-ADP | - |
Artemisia annua | |
| 2',5'-ADP | - |
Homo sapiens | |
| NADP+ | - |
Arabidopsis thaliana | |
| NADP+ | - |
Artemisia annua | |
| NADP+ | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00071 | - |
NADPH | at pH 7.5 and 25°C | Homo sapiens | |
| 0.00102 | - |
NADPH | at pH 7.5 and 25°C | Arabidopsis thaliana | |
| 0.0086 | - |
NADPH | at pH 7.5 and 25°C | Artemisia annua | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Artemisia annua | - |
- |
- |
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADPH + H+ + ferricyanide | - |
Homo sapiens | NADP+ + ferrocyanide | - |
? | |
| NADPH + H+ + ferricyanide | - |
Arabidopsis thaliana | NADP+ + ferrocyanide | - |
? | |
| NADPH + H+ + ferricyanide | - |
Artemisia annua | NADP+ + ferrocyanide | - |
? | |
| NADPH + H+ + ferricytochrome c | - |
Homo sapiens | NADP+ + ferrocytochrome c | - |
? | |
| NADPH + H+ + ferricytochrome c | - |
Arabidopsis thaliana | NADP+ + ferrocytochrome c | - |
? | |
| NADPH + H+ + ferricytochrome c | - |
Artemisia annua | NADP+ + ferrocytochrome c | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATR2 | - |
Arabidopsis thaliana |
| CPR | - |
Homo sapiens |
| CPR | - |
Artemisia annua |
| cytochrome P450 reductase | - |
Homo sapiens |
| cytochrome P450 reductase | - |
Arabidopsis thaliana |
| cytochrome P450 reductase | - |
Artemisia annua |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | 3.7 | ferricytochrome c | at pH 7.5 and 25°C | Arabidopsis thaliana | |
| 20 | - |
ferricytochrome c | at pH 7.5 and 25°C | Homo sapiens | |
| 26.4 | - |
ferricyanide | at pH 7.5 and 25°C | Homo sapiens | |
| 51.4 | - |
ferricytochrome c | at pH 7.5 and 25°C | Artemisia annua | |
| 146 | - |
ferricyanide | at pH 7.5 and 25°C | Arabidopsis thaliana | |
| 169 | - |
ferricyanide | at pH 7.5 and 25°C | Artemisia annua | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Homo sapiens | |
| FAD | - |
Arabidopsis thaliana | |
| FAD | - |
Artemisia annua | |
| FMN | - |
Homo sapiens | |
| FMN | - |
Arabidopsis thaliana | |
| FMN | - |
Artemisia annua | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00056 | - |
2',5'-ADP | at pH 7.5 and 25°C | Homo sapiens | |
| 0.00056 | - |
2',5'-ADP | at pH 7.5 and 25°C | Arabidopsis thaliana | |
| 0.00071 | - |
NADP+ | at pH 7.5 and 25°C | Homo sapiens | |
| 0.00091 | - |
2',5'-ADP | at pH 7.5 and 25°C | Artemisia annua | |
| 0.00102 | - |
NADP+ | at pH 7.5 and 25°C | Arabidopsis thaliana | |
| 0.0086 | - |
NADP+ | at pH 7.5 and 25°C | Artemisia annua | |
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Release 2023.1 (January 2023)
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