Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-dichlorophenolindophenol | inhibition of NADPH-specific enzyme | Bos taurus | |
aminopterin | 0.025 mM, 50% inhibition of NADH-specific enzyme, 1 mM, 50% inhibition of NADPH-specific enzyme | Bos taurus | |
L-thyroxine | mixed-type inhibition | Bos taurus | |
methopterin | 0.038 mM, 50% inhibition of NADH-specific enzyme; 0.7 mM, 50% inhibition of NADPH-specific enzyme | Bos taurus | |
NADP+ | competitive vs. NADPH | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
tetrahydrobiopterin | NADH-specific liver enzyme, cofactor NADPH | Bos taurus | |
0.0014 | - |
6-methyl-tetrahydropterin | NADPH-specific liver enzyme, cofactor NADPH | Bos taurus | |
0.0014 | - |
NADPH | NADPH specific liver enzyme, substrate 6-methyl-tetrahydropterin | Bos taurus | |
0.0015 | - |
NADH | NADH-specific liver enzyme, substrate tetrahydrobiopterin | Bos taurus | |
0.0016 | - |
tetrahydrobiopterin | NADH-specific liver enzyme, cofactor NADH | Bos taurus | |
0.0017 | - |
NADPH | NADPH specific liver enzyme, substrate tetrahydrobiopterin | Bos taurus | |
0.0056 | - |
6-methyl-tetrahydropterin | NADH-specific liver enzyme, cofactor NADH | Bos taurus | |
0.0058 | - |
6-methyl-tetrahydropterin | NADH-specific liver enzyme, cofactor NADPH | Bos taurus | |
0.0068 | - |
tetrahydrobiopterin | NADPH-specific liver enzyme, cofactor NADPH | Bos taurus | |
0.013 | - |
6-methyl-tetrahydropterin | NADPH-specific liver enzyme, cofactor NADH | Bos taurus | |
0.074 | - |
NADH | NADH specific liver enzyme, substrate tetrahydrobiopterin | Bos taurus | |
0.095 | - |
NADPH | NADH specific liver enzyme, substrate 6-methyl-tetrahydropterin | Bos taurus | |
2.9 | - |
NADH | NADPH specific liver enzyme, substrate 6-methyltetrahydropterin | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
quinonoid 6-methyl-7,8-(6H)-dihydropterin + NAD(P)H | - |
Bos taurus | 6-methyl-5,6,7,8-tetrahydropterin + NAD(P)+ | - |
? | |
quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H | - |
Bos taurus | 5,6,7,8-tetrahydrobiopterin + NAD(P)+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | liver: 2 distinct dihydropteridine reductases which catalyze the conversion of the quinonoid dihydropteridine to tetrahydropterin: NADH-dihydropteridine reductase, DPR, utilizes NADH as a better substrate than NADPH, NADPH-specific dihydropteridine reductase, TPR, shows strict specificity for NADPH | Bos taurus | |
NADPH | liver: 2 distinct dihydropteridine reductases which catalyze the conversion of the quinonoid dihydropteridine to tetrahydropterin: NADH-dihydropteridine reductase, DPR, utilizes NADH as a better substrate than NADPH, NADPH-specific dihydropteridine reductase, TPR, shows strict specificity for NADPH | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0032 | - |
NADP+ | - |
Bos taurus | |
0.016 | - |
L-thyroxine | - |
Bos taurus |