Application | Comment | Organism |
---|---|---|
medicine | PYCR2 is highly expressed in colorectal cancer patients and high PYCR2 expression is associated with advanced stage, adenocarcinoma, nodal metastasis, and poor survival rate. PYCR2 knockdown reduces cell viability, proliferation, migration, and invasion and increases apoptosis. PYCR2 knockdown increases Bax, cleaved caspase-3, and cleaved PARP levels and decreases Bcl-2, MMP-2, MMP-9, p-PI3K, p-AKT, and p-mTOR levels in colorectal cancer cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96C36 | isoform PYRC2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colorectal cancer cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PYCR2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | PYCR2 knockdown reduces cell viability, proliferation, migration, and invasion and increases apoptosis. PYCR2 knockdown increases Bax, cleaved caspase-3, and cleaved PARP levels and decreases Bcl-2, MMP-2, MMP-9, p-PI3K, p-AKT, and p-mTOR levels in colorectal cancer cells | Homo sapiens |