Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
butanoyl-CoA + acceptor | Mus musculus | - |
but-2-enoyl-CoA + reduced acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
BALB/cJ mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
butanoyl-CoA + acceptor | - |
Mus musculus | but-2-enoyl-CoA + reduced acceptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SCAD | - |
Mus musculus |
short-chain acyl-CoA dehydrogenase | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | short-chain acyl-CoA dehydrogenase-deficient mice, SCAD-/- mice, have increased brown adipose tissue mass as well as modest cardiac hypertrophy. Uncoupling protein-1 is reduced by 70% in brown adipose tissue, not due to a change in mitochondrial number, nor to decreased signal transduction through protein kinase A, which is known to be a major regulator of uncoupling protein-1 expression, phenotype, overview. Reduced brown adipose tissue function is not the major factor causing cold sensitivity in acyl-CoA dehydrogenase knockout strains, but other mechanisms such as shivering capacity, cardiac function, and reduced hepatic glycogen stores are involved | Mus musculus |