Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(3-(furan-2-yl)-4,5-dihydro-5-(pyridin-4-yl)pyrazol-1-yl)ethanone | - |
Bos taurus | |
2,4-dichloro-6-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol | - |
Bos taurus | |
2-(3-phenyl-1H-pyrazol-5-yl)aniline | - |
Bos taurus | |
2-(4-chlorophenyl)-5-(3,4-dimethoxyphenyl)-5,6-dihydropyrazolo[1,5-c]quinazoline | - |
Bos taurus | |
2-methoxy-4-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol | - |
Bos taurus | |
2-phenylpyrazolo[1,5-c]quinazoline | - |
Bos taurus | |
2-[3-(4-chlorophenyl)-1H-pyrazol-5-yl]aniline | - |
Bos taurus | |
4-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)benzonitrile | - |
Bos taurus | |
4-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol | - |
Bos taurus | |
4-[2-(4-chlorophenyl)-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl]-2-methoxyphenol | - |
Bos taurus | |
4-[2-(4-chlorophenyl)-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl]phenol | - |
Bos taurus | |
5-(1H-indol-3-yl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline | - |
Bos taurus | |
5-(2-nitrophenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline | - |
Bos taurus | |
5-(3,4-dimethoxyphenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline | - |
Bos taurus | |
5-(3-nitrophenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline | - |
Bos taurus | |
allopurinol | 59.2% inhibition at 0.05 mM | Bos taurus | |
curcumin | - |
Bos taurus | |
febuxostat | - |
Bos taurus | |
FYX-051 | - |
Bos taurus | |
additional information | rational design, synthesis, and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives, molecular docking into the enzyme's active site, structure activity relationship, overview. Mode of binding and important interactions such as hydrogen bonding, Pi-Pi stacking with amino acid residues like Ser876, Thr1010, Phen914, Phe1009, and Phe649 with close proximity to dioxothiomolybdenum | Bos taurus | |
N-(1-(3-bromophenyl)-3-(naphthalen-2-yl)-3-oxopropyl)acetamide | - |
Bos taurus | |
Y-700 | - |
Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Molybdenum | in dioxothiomolybdenum cofactor | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P80457 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Bos taurus | - |
milk | - |
Bos taurus | - |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
22 | - |
assay at room temperature | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
molybdenum cofactor | dioxothiomolybdenum cofactor | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.011 | - |
pH 7.5, 22°C | Bos taurus | 2,4-dichloro-6-(2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazolin-5-yl)phenol | |
0.021 | - |
pH 7.5, 22°C | Bos taurus | 5-(3-nitrophenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline | |
0.0316 | - |
pH 7.5, 22°C | Bos taurus | allopurinol | |
0.0417 | - |
pH 7.5, 22°C | Bos taurus | 2-(3-phenyl-1H-pyrazol-5-yl)aniline | |
0.0437 | - |
pH 7.5, 22°C | Bos taurus | 5-(3,4-dimethoxyphenyl)-2-phenyl-5,6-dihydropyrazolo[1,5-c]quinazoline |