Cloned (Comment) | Organism |
---|---|
COS expression analysis in plants with Mg2+ or Mn2+ feeding or without, overview | Tanacetum parthenium |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required for parthenolide biosynthesis in plants, activates the enzyme | Tanacetum parthenium | |
Mn2+ | required for parthenolide biosynthesis in plants, activates the enzyme | Tanacetum parthenium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 | Tanacetum parthenium | - |
(+)-costunolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tanacetum parthenium | - |
cv. Zardband | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
leaf | - |
Tanacetum parthenium | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
germacra-1(10),4,11(13)-trien-12-oate + [reduced NADPH-hemoprotein reductase] + O2 | - |
Tanacetum parthenium | (+)-costunolide + [oxidized NADPH-hemoprotein reductase] + 2 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
COS | - |
Tanacetum parthenium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH-hemoprotein reductase | A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ | Tanacetum parthenium |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is one of the key players in the parthenolide biosynthesis, pathway overview | Tanacetum parthenium |