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Literature summary for 1.14.13.39 extracted from

  • Rouaud, F.; Romero-Perez, M.; Wang, H.; Lobnysheva, I.; Ramassamy, B.; Henry, E.; Tauc, P.; Giacchero, D.; Boucher, J.L.; Deprez, E.; Rocchi, S.; Slama-Schwok, A.
    Regulation of NADPH-dependent nitric oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue (2014), Oncotarget, 5, 10650-10664 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
inhibitor NS1 is a new prototype of a reversible inhibitor of constitutive NOS targeting their reductase domain. NS1 is designed by molecular modelling, by replacing the imbedded NADP cofactor in neuronal NOS reductase domain. NS1 shares with NADPH the nucleotide moiety that allows proper targeting to the NADPH site. NS1 competes with NADPH binding Homo sapiens
inhibitor NS1 is a new prototype of a reversible inhibitor of constitutive NOS targeting their reductase domain. NS1 is designed by molecular modelling, by replacing the imbedded NADP cofactor in neuronal NOS reductase domain. NS1 shares with NADPH the nucleotide moiety that allows proper targeting to the NADPH site. NS1 competes with NADPH binding Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus P70313
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell
-
 Homo sapiens
-
aorta
-
 Mus musculus
-
melanocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
NO-synthase
-
 Homo sapiens
NO-synthase
-
 Mus musculus
NOS
-
 Homo sapiens
NOS
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
 inhibitor NS1 pH and temperature not specified in the publication Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.04
-
 pH and temperature not specified in the publication Mus musculus inhibitor NS1