Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
nucleus pulposus | - |
Homo sapiens | - |
nucleus pulposus | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
PHD3 | - |
Homo sapiens |
PHD3 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | TNF-alpha and IL-1beta robustly increase PHD3 expression in an NF-kappaB dependent fashion | up |
Rattus norvegicus | TNF-alpha and IL-1beta robustly increase PHD3 expression in an NF-kappaB dependent fashion | up |
General Information | Comment | Organism |
---|---|---|
malfunction | loss-of function studies show that PHD3 serves as a co-activator of NF-kappaB signaling activity in NP cells. PHD3 interacts with, and co-localizes with, p65 | Homo sapiens |
malfunction | silencing PHD3 leads to a significant decrease in TNF-alpha-induced expression of catabolic markers that include ADAMTS5, syndecan4, MMP13, and COX2, and at the same time, there is restoration of aggrecan and collagen type II expression | Homo sapiens |
physiological function | by positively controlling NF-kappaB signaling activity, PHD3 promotes the catabolic effects of the inflammatory cytokines on nucleus pulposus cells | Rattus norvegicus |