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Literature summary for 1.14.11.66 extracted from

  • Xiang, Y.; Yan, K.; Zheng, Q.; Ke, H.; Cheng, J.; Xiong, W.; Shi, X.; Wei, L.; Zhao, M.; Yang, F.; Wang, P.; Lu, X.; Fu, L.; Lu, X.; Li, F.
    Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1 (2019), Cancer Res., 79, 86-98 .
    View publication on PubMed
Search for more literature for 1.14.11.66

Organism

Organism UniProt Comment Textmining
Homo sapiens O94953 ioform KDM4B
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Source Tissue

Source Tissue Comment Organism Textmining
MCF-10A cell
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 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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T-47D cell
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 Homo sapiens
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ZR-75-30 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
KDM4B
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 Homo sapiens

General Information

General Information Comment Organism
physiological function in cancer cells, H3K9me3 is largely enriched in long interspersed nuclear element-1 (LINE-1). A significant proportion of KDM4B-dependent H3K9me3 is located in evolutionarily young LINE-1 elements, which likely retain retrotransposition activity. Ectopic expression of KDM4B promotes LINE-1 expression, while depletion of KDM4B reduces it. KDM4B overexpression enhances LINE-1 retrotransposition efficacy, copy number, and associated DNA damage. Breast cancer cell lines expressing high levels of KDM4B also exhibit increased LINE-1 expression and copy number compared with other cell lines. Pharmacologic inhibition of KDM4B significantly reduces LINE-1 expression and DNA damage in breast cancer cells with excessive KDM4B Homo sapiens