Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required | Streptomyces clavuligerus | |
Fe2+ | conformation during catalytic reaction | Streptomyces clavuligerus | |
Fe2+ | isozyme CS2, five and six-coordinate ferrous species in the enzyme-substrate complexes, structural model of conversion for the different reactions | Streptomyces clavuligerus | |
Fe2+ | no ligand switching among the histidine residues of the protein | Streptomyces clavuligerus | |
Fe2+ | isozyme CS2, a single ferrous active site | Streptomyces clavuligerus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
guanidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
clavaminate + succinate + CO2 + H2O | - |
? | |
additional information | Streptomyces clavuligerus | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | ? | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | Streptomyces clavuligerus | - |
dihydroclavaminate + succinate + CO2 + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces clavuligerus | - |
2 isozymes CS1 and CS2 | - |
Streptomyces clavuligerus | - |
isozyme CS2 is encoded on orf5 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 = amidinoproclavaminate + succinate + CO2 | this reaction is due to a proclavaminate amidinohydrolase PAH, gene cla | Streptomyces clavuligerus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxyamidinoproclavaminate + 2-oxoglutarate + O2 | this reaction is due to a proclavaminate amidinohydrolase, i.e. cla | Streptomyces clavuligerus | amidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | guanidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
deoxyguanidinoproclavaminate + 2-oxoglutarate + O2 | hydroxylation | Streptomyces clavuligerus | guanidinoproclavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
dihydroclavaminate + 2-oxoglutarate + O2 | cyclization | Streptomyces clavuligerus | clavaminate + succinate + CO2 + H2O | - |
? | |
additional information | specific for 2-oxoglutarate | Streptomyces clavuligerus | ? | - |
? | |
additional information | biosynthesic pathway of clavulanic acid, a beta-lactamase inhibitor | Streptomyces clavuligerus | ? | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | - |
Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? | |
proclavaminate + 2-oxoglutarate + O2 | saturation | Streptomyces clavuligerus | dihydroclavaminate + succinate + CO2 + H2O | - |
? |