Activating Compound | Comment | Organism | Structure |
---|---|---|---|
catalase | - |
Rattus norvegicus | |
Cs+ | increase of activity | Rattus norvegicus | |
GSH/GSH-peroxidase | increase of activity, more efficient in assay and during preincubation than catalase, protects the enzyme from increasing phosphate concentrations | Rattus norvegicus | |
K+ | efficient coupling of decarboxylation and hydroxylation, stimulation | Rattus norvegicus | |
NH4+ | increase of activity | Rattus norvegicus | |
Rb+ | increase of activity | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-Bromo-2-oxoglutarate | noncompetitive inhibition, 2-oxoglutarate as variable substrate | Rattus norvegicus | |
3-glutathione-2-oxoglutarate | noncompetitive to 2-oxoglutarate | Rattus norvegicus | |
DL-carnitine | - |
Rattus norvegicus | |
phosphate | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.029 | - |
gamma-butyrobetaine | - |
Rattus norvegicus | |
0.052 | - |
L-carnitine | - |
Rattus norvegicus | |
0.47 | - |
D-carnitine | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Rattus norvegicus | 5737 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | requirement | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-trimethylammoniobutanoate + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2 | - |
? | |
D-carnitine + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-carboxy-N,N,N-trimethyl-2-oxopropan-1-aminium + succinate + CO2 | - |
r | |
L-carnitine + 2-oxoglutarate + O2 | - |
Rattus norvegicus | 3-carboxy-N,N,N-trimethyl-2-oxopropan-1-aminium + succinate + CO2 | - |
r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ascorbate | - |
Rattus norvegicus |