Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Rattus norvegicus | rate-limiting enzyme in L-tryptophan catabolism and thus a key serotonergic determinant | N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary hepatocyte | Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | rate-limiting enzyme in L-tryptophan catabolism and thus a key serotonergic determinant | Rattus norvegicus | N-formyl-L-kynurenine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | TDO is regulated by heme, its prosthetic moiety, as its expression and function are significantly reduced after acute hepatic heme depletion | Rattus norvegicus |