Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P39654 | isoform 12/15 lipoxygenase, cf. EC 1.13.11.31 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic islet | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
12/15 lipoxygenase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | a sharp increase in protein expression of 12/15 lipoxygenase is found in the pancreatic islets of 10-week old db-/- obese diabetic mice compared to 8-week old counterparts | up |
General Information | Comment | Organism |
---|---|---|
physiological function | a sharp increase in protein expression of 12/15 lipoxygenase is found in the pancreatic islets of 10-week old db-/- obese diabetic mice compared to 8-week old counterparts. The increase in islet 12/15 lipoxygenase parallels a decline in islet number. A 2- to 3fold increase especially in 12(S)-hydroperoxytetraeicosanoid acid mirrors the increase in 12/15 lipoxygenase expression in islets. A significant increase of platelet 12/15 lipoxygenase gene expression is found along with 12-hydroperoxytetraeicosanoid acids and 15-hydroperoxytetraeicosanoid acids | Mus musculus |